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Dr. Gedde's Credentials
Dr. Margaret Gedde, MD, PhD is an award-winning physician-scientist with intensive training in conventional medicine and medical research.
Dr. Gedde practices holistic, integrative medicine, with a focus on natural hormone balance and anti-aging.
Currently she is not taking patients.
Healing Philosophy Full Curriculum Vitae
CREDENTIALS SUMMARY
- BA, Biochemistry, Columbia University, 1981
- MD, Stanford University, 1993
- PhD, Biophysical Chemistry, Stanford University, 1993
- Residency, Pathology & Laboratory Medicine, University of Pennsylvania, 1993-1997
- Board Certification, Clinical Pathology, 1997
- Howard Hughes Medical Institute Physician Postdoctoral Fellow, 1996-1999
- Postdoctoral Fellowship, University of California at Berkeley, 1997-1999
- Additional research at world class institutions including The Rockefeller University and Sloan-Kettering Cancer Institute.
Total of a dozen years in molecular
biology, microbiology, protein chemistry, biochemistry and biophysics
research
- Pharmaceutical development director and consultant 1999-2004. I left this work following repercussions from reporting cheating in a drug development
program.
- Hypnotherapist and pioneer in brainwave entrainment technology
- Currently licensed to practice medicine in Colorado. Have been licensed to practice medicine also in Arizona, Pennsylvania & Hawaii.
You can
verify Dr. Gedde's Stanford degrees and Colorado medical license as follows:
- Verify Stanford degrees by contacting the Stanford University School of
Medicine Registrar at (650) 723-5085 and the Stanford University Registrar
at (650) 723-2041.
- Verify
Colorado medical license by searching in the State of Colorado Automated
Licensure Information System at
https://www.doradls.state.co.us/alison.php.
From the Desk of
Dr. Margaret Gedde, MD, PhD
Dear Health Seeker,
I am a conventionally-trained medical doctor. Despite that, I have respect for the human body and ongoing commitment to improve the health of each of my clients and patients.
Here's a bit of my story.
Before medical school, I found the ideas of Adele Davis, Paavo Airola and other pioneer alternative healers deeply inspiring.
In passing through “hoops” earning medical credentials, I met many professors and classmates who
referred to alternative health practitioners as "quacks". I
learned to keep my unconventional ideas to myself - and eventually to set them aside.
Aiming high, I obtained MD and PhD degrees and Board Certification. I enjoyed prestigious research grants and soaked up the environment of world-class institutions.
While academic and accomplished, I was thoroughly disconnected from what supports vibrant health.
My next career step was to work on the clinical development of pharmaceutical drugs. In that industry, I was paid very well.
But over time, I realized that the methods and goals of pharmaceutical companies were not in alignment with mine.
(The sort of thing I observed has come to fruition in drug disasters like Vioxx.)
Eventually I had seen enough, and could not continue to cash their checks in clear conscience. I left the pharmaceutical industry at large financial cost to myself.
Fortunately, at that time I had a general practice blessed with patients who challenged me to look for better options than pharmaceutical drugs.
They wanted therapies that supported the body and respected its intelligence and power to heal.
Working to help my patients, I rediscovered alternative healing.
Also, I was spurred by personal health problems – a bleeding uterine fibroid and severe anemia. Digging intensively, I learned about estrogen dominance,
bioidentical hormone therapy, adrenal fatigue, reverse thyroid block and subject after subject I had never heard of in medical school.
I avoided hysterectomy, and feel special empathy for women who undergo this surgery without hearing about other options.
Now I have come full circle back to my original intentions as a healer. Every day, I have the great pleasure of helping patients
“get their lives back”. This is a deeply satisfying place to be.
Welcome to the cutting-edge world of holistic hormone balancing. My skill, intelligence and good will are at your service.
To your good health,
Margaret Gedde, MD, PhD
Full Curriculum Vitae
Degrees
- 1981 - B.A. Barnard College, Columbia University (Biochemistry) Cum Laude
- 1993 - M.D. Stanford University School of Medicine
- 1993 - Ph.D. Stanford University Department of Chemistry (Biophysical Chemistry)
Clinical Experience
1993 to 1997
University of Pennsylvania Medical Center, Philadelphia, PA
Resident and Clinical Instructor,
Division of Laboratory Medicine,
Department of Pathology and Laboratory Medicine
1994 to 1995
Chief Resident, Division of Laboratory Medicine
1997
Board Certification, Clinical Pathology
- Trained in all areas of the clinical laboratory (including molecular diagnostics, hematology, immunology, coagulation,
transfusion medicine, microbiology and chemistry), with emphasis of diagnosis and therapy of leukemias and lymphomas.
- Worked with virtually all clinical services and therapeutic areas in the hospital through consultations, nightly call, and clinical
rounds. Duties included administering transfusion therapies on the oncology and bone marrow transplant services.
- As Chief Resident, I led morning resident rounds, organized didactic and journal club series, and was liaison to the
administration, facilitating two-way communication between faculty and residents. I addressed resident complaints and practiced
conflict resolution. Organizational duties included planning resident schedules and budgeting program expenses.
- To improve the quality of the clinical pathology resident service, I spearheaded an initiative to completely revise the Clinical
Pathology Resident On Call Manual, and negotiated the purchase of new computers.
- As Clinical Instructor, I taught General Pathology as well as advanced topics to medical students for three years, was invited to
design and give a course on laboratory testing for nurses, and published two continuing education articles.
- In recognition of my research accomplishments, I was asked to
speak as part of a departmental presentation to the new Chairman of
the Board of Trustees of the University of Pennsylvania.
- Memorably, my Chief Resident counterpart in Anatomic Pathology and
I recruited the help of the residency director and department chair
to address tensions that had arisen between residents of different
national backgrounds. Though some people we talked to thought we
should stay away from the issue entirely, we believed it best
to address these tensions openly. Our efforts culminated in
a specially-called meeting of residents and faculty, where the
tensions were resolved. I am proud that this resulted in a healthier
working environment for all residents.
2003 – 2004
Solo General Practice, Maui, Hawaii
- Provided basic medical care in a small general practice,
consulting with specialists and coordinating treatment as needed.
Advocated for patient interests within established medical
structures such as HMOs.
- Special interest in protocols for cleansing/detoxification and for
neurotransmitter rebalancing, for patients experiencing chronic
illness.
2004
Silky Skin Laser Spa, Maui, Hawaii
Medical Director
- Provided laser hair removal and other aesthetic treatments to
client-patients in a relaxing and beautiful medical spa environment.
- Worked hand-in-hand with owners to address medical-legal questions
while developing a viable business model in the demanding Maui
market.
- Developed and implemented a successful marketing program that
included phone contacts, promotions, print and radio ads,
door-to-door contact, and a web presence. Competitive edge was based
on an innovative concept, a high degree of professionalism, and
close attention to client needs.
- Clients showed high levels of loyalty; for example, after the
owners chose to relocate the business in Colorado, one client
elected to receive a follow up treatment at the new location, though
it meant she had to travel from Maui to Colorado, and though
numerous other practices offering the treatment were available to
her.
2004 to present
Medical Practice in Salida, CO
Pharmaceutical Industry Experience
1999 to 2004
Worked at the Director level as an employee then as an independent consultant in pharmaceutical research and development.
I am presently blackballed in the pharmaceutical industry for resigning in protest of drug development cheating regarding a new antibiotic with
potential pandemic and anti-terror uses.
Because of this I no longer provide details of my pharmaceutical development experience on my websites.
Medical and Basic Science
1995 to 1997
University of Pennsylvania School of Medicine, Philadelphia, PA
Postdoctoral Fellow, Department of Microbiology
1997 to 1999
University of California at Berkeley, Berkeley, CA
Postdoctoral Fellow, Department of Molecular and Cell Biology
Advisor: Daniel A. Portnoy
1996 to 1999
Howard Hughes Medical Institute Physician Postdoctoral Fellow
- Demonstrated that the pH-dependence of listeriolysin O (a
pore-forming toxin made by the intracellular pathogen Listeria
monocytogenes) compartmentalizes the activity of this toxin and
prevents premature destruction of the host cell. To accomplish this,
purified and mutagenized listeriolysin O, exchanged mutant alleles
into L. monocytogenes, and investigated effects of mutant and native
protein expression in tissue culture and animal models. Collaborated
synergistically with 3 other laboratory members on this work.
- The work resulted in 3 original research articles (2 as first
author or equivalent), an oral platform presentation at a national
meeting, 3 poster presentations at national and international
meetings, and numerous other oral presentation venues including NIH
Training Grant and School of Public Health seminar series, the UC
Berkeley Molecular and Cell Biology departmental retreat, and the
HHMI Annual Meeting of Fellows.
- In response to my competitive grant application titled “Structural
Basis of the pH Dependence of the Bacterial Pore-Forming Toxin
Listeriolysin O,” was awarded a Howard Hughes Medical Institute
Physician Postdoctoral Fellowship (3 years of support). Was also
supported by an NIH Infectious Diseases and Virology Training Grant.
- Spearheaded the laboratory safety program and personally trained
each laboratory member with regard to biological, chemical,
electrical, and radiation hazards. Trained, supervised and mentored
an undergraduate student who subsequently went on to work in a
biotech startup, and helped train 7 other graduate students,
technicians, and postdocs.
- This postdoctoral work complemented my rigorous chemistry,
biochemistry and biophysics training with hands-on experience in
molecular biology and molecular genetics, equipping me to engage
researchers from a huge range of disciplines in productive
discussions and collaborations.
1986 to 1993
Stanford University, Stanford, CA
Graduate Student, Department of Chemistry
Thesis Advisor: Wray H. Huestis
Thesis: “Cell pH-Mediated Shape Change in the Human Erythrocyte”
- Solved the paradox of pH-associated red cell shape change by
developing assays and mathematical models for red cell physiological
relationships, performing nonlinear multivariate statistical
analysis on a 500-entry dataset, and assessing red cell
protein-membrane interactions using a hydrophobic, radioiodinated,
photoactivatable membrane probe. Also, demonstrated the amphipathic
nature of chlorpromazine binding to plasma membrane components.
- Collaborated synergistically with 2 other graduate students on
this work.
- Supervised and mentored an undergraduate student on the red cell
shape project, who subsequently went on to medical school. Made
numerous research and journal articles presentations to laboratory
and departmental groups. Was supported by a Jameson Research
Foundation Fellowship.
- Relevant to psychopharmacology (action of neuroleptics and general
anesthetics) and biophysical problems in general. Resulted in 4
poster presentations at national meetings and 5 original research
articles, 4 as first author.
- My advisor thanked me for being a voice of calm and moderation in
a group that included several nationalities and some difficult
personalities.
1985 to 1986
Stanford University School of Medicine, Stanford, CA
Medical Student Research Assistant, Department of Neurology
- Developed a chromium-51 assay of damage to cultured neurons and
used it to assess glutamate neurotoxicity. Was supported by a Kevin
Walton Summer Fellowship. Relevant to stroke, epilepsy and trauma.
Resulted in 2 original research articles, 1 as first author.
1984 to 1985
The Rockefeller University, New York, NY
Research Assistant, Laboratory of Metabolism/Pharmacology
- Performed clinical assays of hemoglobin synthesis pathway enzymes
and intermediates using biochemical and organic chemical separations
and assays. Relevant to in-born errors of metabolism and hepatic
metabolic disorders.
1983 to 1984
Memorial Sloan-Kettering Cancer Center, New York, NY
Research Assistant, Laboratory of Developmental Genetics
- Studied the molecular basis of a murine developmental defect using
tissue culture and protein chemistry approaches. Relevant to
congenital disorders and to cancer.
Other Projects
- HGH MD (www.hgh-md.com),
an anti-aging / human growth hormone educational website.
- TheraSounds™ relaxing at-home hypnotherapy (www.hypnosis-tapes.org),
using safe and effective hypnotherapy scripts, brainwave entrainment
and positive affirmations for personal change.
- SusPro (www.suspro.org),
an educational non-profit organization dedicated to developing
methods for sustainable housing, energy, and agriculture. I serve as
donor and spokesperson for this inspiring and worthy organization.
Activities include networking at local and regional functions, and
contacting high-priority potential donors.
Honors and Awards
1985
Kevin Walton Summer Fellowship
1990 to 1992
Jameson Research Foundation Fellowship
1995 to 1996
Infectious Diseases and Virology Training Grant (NIH)
1996 to 1999
Howard Hughes Medical Institute Physician Postdoctoral Research Fellowship
Publications
Thesis
Gedde MM. 1993. Cell pH-mediated shape change in the human erythrocyte. Department of Chemistry, Stanford University.
Original Research Articles
- Maulucci-Gedde M, Choi DW. 1987. Cortical neurons exposed to glutamate rapidly leak preloaded
51-chromium. Experimental Neurology 96:420-429.
- Choi DW, Maulucci-Gedde M, Kriegstein AR. 1987. Glutamate toxicity in cortical cell culture.
Journal of Neuroscience 7:357-368.
- Gedde MM, Yang E, Huestis WH. 1995. Response of human erythrocyte
shape to altered cell pH. Blood 86:1595-1599.
- Mazzaccaro RJ, Gedde MM, Jensen ER, van Santen HM, Ploegh HL,
Rock KL, Bloom BR. 1996. Major histocompatibility class 1
presentation of soluble antigen facilitated by Mycobacterium
tuberculosis infection. Proceedings of the National Academy of
Science, USA 93:11786-11791.
- Gedde MM, Huestis WH. 1997. Membrane potential and human
erythrocyte shape. Biophysical Journal 72:1220-1233.
- Gedde MM, Davis DK, Huestis WH. 1997. Cytoplasmic pH and human
erythrocyte shape. Biophysical Journal 72:1234-1246.
- Gedde MM, Yang E, Huestis WH. 1999. Resolution of the paradox of
red cell changes in low and high pH. Biochimica et Biophysica Acta
1417:246-253.
- Gedde MM, Higgins DE, Tilney LG, Portnoy DA. 2000. Role of
listeriolysin O in cell-to-cell spread of Listeria monocytogenes.
Infection and Immunity 68:999-1003.
- Glomski IJ,* Gedde MM,* Tsang AW, Swanson JA, Portnoy DA. 2002.
The Listeria monocytogenes hemolysin has an acidic pH optimum to
compartmentalize activity and prevent damage to infected host cells.
Journal of Cell Biology 156:1 12.
*These authors contributed equally.
- Baden LR, Critchley IA, Sahm DF, So W, Gedde M, Porter S,
Moellering RC Jr, Eliopoulos G. 2002. Molecular characterization of
vancomycin-resistant enterococci repopulating the gastrointestinal
tract following treatment with a novel glycolipodepsipeptide,
ramoplanin. Journal of Clinical Microbiology 40:1160-3.
- Chen JY, Brunauer LS, Chu FC, Helsel CM, Gedde MM, Huestis WH.
2003. Selective amphipathic nature of chlorpromazine binding to
plasma membrane bilayers. Biochimica Biophysica Acta (Biomembranes)
1616(1):95-105.
Continuing Education Articles
- Gedde MM, Kricka LJ. 1994. Serum ferritin measurement: a case
study approach to quality improvement. Endocrinology and Metabolism
In-Service Training and Continuing Education 12(7):179-183.
- Gedde MM, Kricka LJ. 1994. Rhabdomyolysis. Endocrinology and
Metabolism In-Service Training and Continuing Education 12(9):241-246.
Abstracts
Dec 1989
American Society for Cell Biology, Houston, TX
Gedde MM, Huestis WH. “Roles of internal pH, cell volume, and membrane potential in human erythrocyte pH-induced shape change.” Journal of Cell Biology 109:175a.
Feb 1991
Biophysical Society, San Francisco, CA
Gedde MM, Huestis WH. “Human erythrocyte shape change induced by changes in buffer pH is most dependent on changes in cytoplasmic pH.” Biophysical Journal 59:639a.
Dec 1993
American Society for Cell Biology, New Orleans, LA
Gedde MM, Yang E, Huestis WH. “Hydrophobic protein-lipid associations in human erythrocyte cell pH-mediated shape change.” Molecular Biology of the Cell 4:85a.
Dec 1997
American Society for Cell Biology, Washington, D.C
Gedde MM, Higgins DE, Tilney LG, Portnoy DA. “Role of the pore-forming protein, listeriolysin O, in the cell-to-cell spread of Listeria monocytogenes.”
Molecular Biology of the Cell 8:237a.
Dec 1998
American Society for Cell Biology, San Francisco, CA
Chen JY, Chu FC, Gedde MM, Huestis WH. "Selective electrostatic interactions of chlorpromazine with plasma membrane components." Molecular Biology of the Cell 9:80a.
Feb 1999
Biophysical Society, Baltimore, MD
Gedde MM, Portnoy DA. “Structural basis of the pH-dependence of the pore-forming protein listeriolysin O.” Biophysical Journal 76:22a.
Feb 2000
1st International ASM Conference on Enterococci, Banff, Alberta, Canada
So W, White DJ, Gedde MM. “Comparison of selective media for isolation of vancomycin-resistant enterococci.” February 27 to March 2, 2000.
Feb 2000
1st International ASM Conference on Enterococci, Banff, Alberta, Canada
Baden L, Critchley I, Sahm D, So W, Gedde MM, Porter S, Moellering RC Jr, Eliopoulos G. “Pulsed-field gel electrophoresis of VRE DNA isolated
during a phase II clinical study of the novel glycolipodepsipeptide ramoplanin.” February 27 to March 2, 2000.
May 2000
American Society for Microbiology, Los Angeles, CA
Gedde MM, Glomski IJ, Portnoy DA. “The role of the acidic pH optimum of listeriolysin O in Listeria monocytogenes pathogenesis.” 100th General
Meeting. Abstract D-59, p 239.
Sep 2000
Symposium on Pore-Forming Toxins, Trento, Italy
Glomski IJ, Gedde MM, Portnoy DA. “Increasing the hemolytic activity of listeriolysin O at neutral pH decreases the virulence of Listeria
monocytogenes.” September 14-17, 2000.
Dec 2000
1st Intl Symposium on Resistant Gram-Positive Infections, San Antonio, TX
White DJ, Visweswaran V, So W, Hurst MA, Gedde MM. “Resistance profile of ramoplanin, a novel glycolipodepsipeptide with selective
gram-positive activity.” December 3-5, 2000.
Oct 2001
North American Cystic Fibrosis Conference, Orlando, FL
Loury DL, Gedde MM, Woods DE. "Aerosolized protegrin analog iseganan (IB-367) reduces microbial density in a rat model of lung infection with
Pseudomonas aeruginosa." October 25 28, 2001.
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